Inside Precision Medicine

Prime Editing of Common Variants Reverses Pediatric Brain Disorder in Mice The durable treatment of several mutations for a #neurodevelopmental disorder in vivo has implications for developing personalized #geneediting drugs @davidrliu @jacksonlab hubs.li/Q03ygt0z0

Sanofi Makes $1.6 Billion Bet on Vicebio’s Vaccine Technology Sanofi will acquire #Vicebio, a U.K. biotech developing #respiratory vaccines with its molecular clamp #vaccine technology @sanofi hubs.li/Q03yfT4F0

Uncut GEMS: Epigenetic Editing Aims to Refine Personalized Genetic Medicine Epicrispr CEO Amber Salzman, PhD, describes how an individual's #epigenome can be uniquely edited using the Gene Expression Modulation System (GEMS) @EpicrisprBio #geneediting hubs.li/Q03yvQRl0

Landmark Studies Reveal Complexities of Human Genetic Variation The research provides unprecedented insights into how humans differ from one another and how this could affect their #susceptibility to disease @tobiasmarschal #geneticvariation #genomics hubs.li/Q03yvLqy0

Radiation Primes Resistant Tumors for Immunotherapy #Radiation reshapes “cold” lung tumors, boosting #Tcell activation and making resistant cancers respond to #immunotherapy @ValsamoA #lungcancer hubs.li/Q03yvGRb0

Replimune Viral-Based Therapy for Melanoma Rejected By FDA Replimune's viral-based treatment for advanced melanoma has been rejected by the FDA in a Complete Response Letter @Replimune #clinicaltrials #FDA #melanoma hubs.li/Q03yv3rk0

Chemotherapy Response in Tumors Doubled by Targeting Chromatin Plasticity Researchers found that chromatin, which organizes genetic material within a cell, dictates cancer’s ability to resist treatments @NorthwesternU #chemotherapy #chromatin #cancer hubs.li/Q03yv9rY0

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Boy or Girl? Not Just a Coin Flip A baby’s sex at birth may be influenced by #maternal age and #genetics, according to a genome-wide association study of nearly 60,000 women @siwenwangMD @HarvardChanSPH #GWS hubs.li/Q03ygx290

Muscle-Wasting Syndrome Cachexia Tied to Liver REV-ERBα Disruption REV-ERBα, which actively helps regulate circadian processes, was almost completely shut down during cachexia @HelmholtzMunich #cachexia #geneexpression #liver hubs.li/Q03yglzL0

Epigenetic Prostate Cancer Therapy Shows Promising Early Results Telomir Pharmaceuticals' drug candidate Telomir-1 shows promise in a mouse study for treating advanced prostate cancer @TelomirPharma #prostatecancer #epigenetics #drugdevelopment hubs.li/Q03y2hh20

Engineered Bacteria Provides Detailed Real-Time Imaging for Tumor Resection A new imaging method using the engineered bacteria SAS provides a more accurate delineation of tumor margins than current technologies @KISTKOREA #bacteria #tumors #imaging hubs.li/Q03y2gZP0

Ulcerative Colitis Driven by Risk Gene and Gut Microbiota Interactions A known risk gene for #ulcerativecolitis has been found to interact with pathological gut bacteria to drive disease progression and severity @UOsaka_en #FMT #scRNAseq hubs.li/Q03y22FS0

Promising First Steps Toward a Universal mRNA Cancer Vaccine A new mRNA cancer vaccine, in combination with common immunotherapy drugs, could become the first universal cancer vaccine @UFCTSI #anticancerdrugs #mRNA #vaccines hubs.li/Q03y21q20

Stress-Induced Loop Driving Leukemia Stem Cells in AML Discovered A feedback loop between IL-33 and its receptor IL1RL1 drives self-renewal of LSCs and contributes to treatment resistance @muschollings #AML #stemcells #stress hubs.li/Q03xT9VW0

Liver Cancer Ablation Success May Be Boosted by Blocking Galectin-1 UCLA researchers have shown that Galectin-1 fuels metabolism that helps liver tumors resist thermal ablation @dgsomucla #ablation #livercancer #immunotherapy hubs.li/Q03xTd260

Robotic “Copilot” Autonomously Assists with Surgery An open-source, artificial intelligence simulator can train surgical robots to autonomously perform multi-stage tasks during laparoscopic operations @CUHKofficial #robotics #AI #surgery hubs.li/Q03xVBkX0

Obesity-Linked Cancer Death Rate Triples in U.S. Cancer deaths linked to obesity have tripled in the U.S. over the past two decades, according to a study presented Sunday at ENDO @HMHNewJersey #obesity #cancer hubs.li/Q03xT2-R0

AI Anomaly Detection Model Enhances Tumor Localization in Breast MRI AI detects breast cancer on MRI with precise, explainable heatmaps @Microsoft @UW #AI #MRI #breastcancer hubs.li/Q03xT2ZT0

New Preeclampsia Risk Strategy Guidelines Miss the Mark USPSTF #guidelines for AP in #preeclampsia prevention fall short due to weak predictive value of moderate-risk factors @MirvieDx @MassGenBrigham #aspirin hubs.li/Q03xVCgB0