Fred Hutch Innovation Lab
@HutchInnovation
FHIL is leading the in-house development and early adoption of powerful new single-cell and spatial technologies to spur discoveries in cancer immunology.
It's Xenium Prime Days at FHIL. Spatial over shopping! Our first Prime run started yesterday on some unique samples, 4 per slide-What a deal! Ready to load tomorrow.
We are pleased to share our work evaluating some of the latest single-cell platforms, including updated chemistries, in two separate experiments using peripheral blood mononuclear cells (PBMCs). biorxiv.org/cgi/content/sh…
Just released today in Nature Methods. If you haven't tried Proseg's cell segmentation method on your spatial transcriptomic data yet, maybe you should. See how it stacks up to other methods with data from multiple platforms. nature.com/articles/s4159…
What factors enable CAR-Ts to respond to checkpoint blockade, and can they be engineered to be more sensitive to enhancement? We explore this question in our lab’s first pre-print, led by MSTP student @AndrewAJSnyder1 with great collaborations with @EvNewell1 and @ScottFurlan. 1/
Modulating AP-1 enables CAR-T cells to establish an intratumoral PD-1+Tcf1+ stem-like reservoir and overcomes resistance to PD-1 axis ... biorxiv.org/content/10.110… #biorxiv_immuno