HemaSphere Journal (IF = 14.6)

This recently published paper highlights the essential role of TET3 in hematopoiesis. Loss of TET3 in fetal liver and adult bone marrow reduces LT-HSCs and their colony-forming capacity. Increased DNA methylation of cell cycle regulators underpins reduced quiescent…

🔥This NLG biomarker-driven study shows that intensive immunochemotherapy combined with early HD-Mtx and HD-AraC as consolidation is feasible and effective in patients with biologically high-risk LBCL.  @LeppaSM 👉bit.ly/4mdhPK6

🩺 Enhance your clinical practice with HemaSphere Journal! Access harmonized #guidelines and the latest research to improve patient care. Find them in our virtual bookshelf 📖 bit.ly/4kETU4u  #Hematology #ClinicalPractice #PatientCare

🎧Replay🎧 Host Dr Charles de Bock engages with Professor Hélène Cavé and Dr. Marion Strullu to discuss their recent study on juvenile myelomonocytic leukemia (JMML). They delve into the complexities of diagnosing JMML, the genetic mutations associated with the disease, and the…

🎬Behind the Scenes! We promise, the poster is the scariest part of this podcast! In this upcoming episode of the HemaSphere podcast, Scientific Editor Dr Charles de Bock delves into the fascinating world of cellular metabolism and its critical role in cancer biology. Our…

Sickle cell disease (#SCD) still impacts life expectancy and quality of life despite recent improvements, plus the disease's variability makes predicting severity and therapy response challenging. While HSCT offers a potential cure, it's limited by the availability of…

The expanded 12-color cytometric panel enhances MRD detection in BCP-ALL, especially for patients treated with CD19-targeted therapies. It offers improved B-cell lineage definition and additional information on CD22 expression, showing excellent concordance with molecular MRD…

HemaTopics are HemaSphere publications focusing on 🔥hot hematology topics including recent research developments, updates on diagnosis and treatment, policy and guidelines news, and more. This week we focus on the latest HemaTopic by Scientific Editor S Hibbs, which discusses…

Significant contribution of exome and genome sequencing in diagnosing congenital neutropenia (#CN).  This study highlights the importance of advanced genetic testing in diagnosing CN, given its phenotypic overlap, genetic heterogeneity, and variable penetrance of immunological…

🎧 Replay!  In this episode of the HemaSphere podcast, host Dr Charles De Bock engages with experts Professor Jan Cools, Professor Heidi Segers, and Dr Margo Aertgeerts to discuss their recent study on acute lymphoblastic leukemia (ALL). They explore the advancements in…

PET/CT is crucial for staging #MM and detecting extramedullary disease, however its role in CAR T cell therapy patients remains unclear.  Read this article further in our recent issue 👉bit.ly/3TnSbVQ

📰 Immune Thrombotic Thrombocytopenic Purpura (#iTTP)  is a rare disease that primarily affects individuals aged 20-40 years. Authors show results indicate caplacizumab is effective in reducing refractoriness, risk of death & likelihood of exacerbations in elderly patients,…

How do we better understand the biology behind therapy-related myeloid neoplasia (tMN) or predict who is at risk?   👉bit.ly/4jAzbOA

NK-large granular lymphocyte leukemia (#NK-LGLL) is driven by constitutive activation of cellular pathways and chronic inflammation, highlighting the microenvironment's central role in its pathogenesis. Recent genetic and epigenetic advances reveal new vulnerabilities, promising…

1/ Out now in @Hemasphere_EHA. Interesting authorship this - consisting of some academic physicians, Chair of @SickleCellUK and a fantastic patient advocate. We discuss the impact of recent approvals and reversals in sickle on the community. A short🧵 #OpenAccess

#ALL is the most common malignancy in pediatric patients. A nationwide study of 270 Korean pediatric patients with high-risk or relapsed ALL undergoing their first allogeneic HSCT found comparable outcomes between myeloablative TBI-based and chemotherapy-based conditioning…

Hello, all! We are still here so no worries, but if you are choosing to move to Bluesky, we are there as well. Happy to have your interactions, so please give us a follow if prefer. 🤗

#ESHBMFS2026: REGISTRATION IS OPEN! More information ➡ bit.ly/4lcJlpV ESH-EBMT-EHA-IPIG 4th Translational Research Conference: Bone Marrow Failure & Leukaemia Predisposition Syndromes Chairs:@CarmemBonfim1 @brummendorf A. Risitano @SharonSavageMD #ESHCONFERENCES #bmfsm

The current July issue is now open!   👉bit.ly/4m30KlB

In this Review Article published in the June issue of HemaSphere,  new pharmacological treatments have the potential to address unmet needs by direct oral anticoagulants in acute and long-term management and prevention of venous thromboembolism. 👉bit.ly/4kkTd0M…