Molecular Instruments

#onlywithHCR: Hearing the Genes Sing—Transcriptomic Disruption in the Songbird Brain Using songbird courtship song as a model, Colquitt et al. mapped how the loss of auditory feedback destabilizes learned motor behaviors. With #HCRtechnology, they were able to observe the…

We're excited to announce major upgrades to the HCR™ platform, making clinical-grade performance more accessible than ever. 🧬 HiFi Architecture now powers high-specificity detection of miRNAs and siRNAs, enabling robust detection of short RNA targets with unmatched…

#onlywithHCR: Cracking the Code of Smell—Unexpected Co-Receptor Overlap in Drosophila 🦟 In a groundbreaking study, Task et al. successfully mapped the expression of all major chemosensory co-receptors in Drosophila melanogaster. With #HCRtechnology, the researchers revealed…

It’s time to meet the judges! We’re excited to introduce our panel of scientific experts representing diverse fields. These leaders will be reviewing all entries anonymously and casting their votes to determine the 2025 3D Imaging World Cup’s finalists. Swipe to explore our…

With HCR™ Pro, we’re redefining what’s possible for RNA detection – delivering ultra-sensitive detection ideal for low-abundance targets or highly autofluorescent samples. In this case study, Dr. Douglas Houston from the University of Iowa used HCR™ Pro to reveal clear…

Join us for a Lunch & Learn at the Harvard Center for Biological Imaging! This session will feature a talk by Dr. Aneesh Acharya, who will share exciting updates and innovations made possible #onlywithHCR. 📍 16 Divinity Ave, BioLabs RM1080 🗓️ July 22nd, 2025 at 12:00 PM…

#onlywithHCR: Unraveling Evolution in the Dark—Genetic Links Between Sleep and Albinism in Cavefish 🐟 In a remarkable study of evolutionary biology, O’Gorman et al. explored how multiple traits evolve in tandem in Astyanax mexicanus. Surface-cave F2 hybrids revealed a…

We’re thrilled to be at the 19th International Zebrafish Conference (IZFC) this week in Madison, Wisconsin! Visit us at Booth #6 to meet our team – Aneesh Acharya (Chief Commercial Officer, and Megan Le (Marketing Associate) – and explore how HCR™ Gold and HCR™ Pro can elevate…

HCR™ Pro RNA-ISH for manual workflows delivers high-fidelity RNA-ISH signal across both brightfield and fluorescence detection modalities – giving you flexibility without having to buy new probes. Brightfield: Streamline imaging and analysis with Matisse® chromogens. Ideal for…

Say hello to Brian Kang, Kelly Tran, Britney Lozano, and Caitlyn Starman—the talented team responsible for manufacturing every HCR™ amplifier we ship! As part of our core manufacturing operations, this team oversees the complete lifecycle of our HCR™ amplifiers, from synthesis…

#onlywithHCR: Tracing Evolution at the Root—Single-Cell Insights Across Grasses 🌾 In a compelling cross-species study, Guillotin et al. unveiled how domesticated grasses evolved distinct traits through fine-scale changes in root cell types. With #HCRimaging, the team mapped…

We had a great time in San Juan at the 20th International Congress of Developmental Biology conference, connecting with the vibrant developmental biology community! From engaging poster sessions with Dr. Douglas Houston to thoughtful conversations at our booth, it was exciting to…

HCR™ Pro Detect kits for the DISCOVERY ULTRA are now available in pre-filled, ready-to-use (RTU) format HCR™ Pro Detect kits for the DISCOVERY ULTRA platform are now available in a pre-filled, RTU format – designed to minimize hands-on time, streamline setup, and improve…

#onlywithHCR: Illuminating Bacterial–Fungal Interactions with Intra-Hyphal Resolution In an exciting study, Morales et al. explore the hidden world of bacterial–fungal interactions (BFI). While amplicon sequencing has hinted at co-occurrence patterns, the real challenge has been…

We’re excited to be in San Juan, Puerto Rico this week for the 20th International Congress of Developmental Biology (ICDB)! Catch us during Poster Session C on Saturday (June 21) from 2:00 – 5:00 PM, where we’ll be showcasing powerful applications #onlywithHCR. Be sure to also…

It’s your time to shine! The 3D Imaging World Cup 2025 is in full swing—we’ve gotten so many amazing Light-Sheet image submissions and are excited to see the rest roll in. Enter your submission here: alpenglowbiosciences.com/3d-imaging-wor…

Introducing HCR™ Pro RNA-ISH for Manual Workflows We're excited to announce the launch of HCR™ Pro RNA-ISH for manual workflows, bringing the extreme sensitivity of enzymatic amplification to researchers working with low-abundance targets and challenging samples. From…