Ashish Srinivasan MD PhD
@Gastro_Ash
Gastroenterologist 🇦🇺 | #IBD Researcher | #MedEd Alum: Oxford, UK #IBD | Erlangen, Germany #IUS Father | Foodie | sports Fan
Thanks for shining a spotlight on this important aspect of placebo-controlled drug clinical trials in #IBD. Here’s to hoping for more active comparator trials moving forward. 🤞🏽
Several stakeholders have advocated for minimising placebo controlled RCTs. We analysed the harms [Adverse Events,[AEs]] associated with placebo in inflammatory bowel diseases (IBD) RCTs. @alex_ford12399 @Bealoquebea @Jonathansegal85 @JonnyBlackwell @DrCJBlack @GastroRes_Leeds
🔍 Deep dive into #MRE disease activity scores in luminal & post-op #Crohns 🤝 A true #IBD x #radiology collab ❓How do we assess activity on MRE ❓Should we use scores like colonoscopy? Which one? ❓What’s holding us back? 📖 Read here: doi.org/10.3748/wjg.v3… #GITwitter
To complement our recent study on #biologic safety in #IBD post–#liver #transplant, here’s our JAK inhibitor case series 👥 8 patients: 4 TOF, 1 UPA, 3 switched TOF→UPA ❌ No serious infections ⏳ 17-month median follow-up JCC 2024 📄 doi.org/10.1093/ecco-j…
📌Biologic safety in #IBD post liver transplant - what’s safest? 💊Gut-specific (VDZ) v systemic (aTNF, UST) agents = similar infectious events ⚠️ Steroid co-therapy = ⬆️ severe infections Out in AP&T 🔗doi.org/10.1111/apt.70… 👏Congrats #SimoneChin! #GITwitter #livertwitter
Read 'open access' via bit.ly/3GBA5gz "Systemic Biologics Have Similar Safety to Vedolizumab in Inflammatory Bowel Disease Patients Following Liver Transplantation"
📌Biologic safety in #IBD post liver transplant - what’s safest? 💊Gut-specific (VDZ) v systemic (aTNF, UST) agents = similar infectious events ⚠️ Steroid co-therapy = ⬆️ severe infections Out in AP&T 🔗doi.org/10.1111/apt.70… 👏Congrats #SimoneChin! #GITwitter #livertwitter
Here’s our practical guide to prescribing #IBD therapies in patients with #CKD, including #ESRF—online @APTjournal! Written in collaboration with renal & pharmacy colleagues. 👏 Great work #LynnaChen! @VasudevanAbhi 🔗 doi.org/10.1111/apt.70… #GITwitter
Cardiometabolic diseases in IBD - all you need to know courtesy of our IBD Fellow #KrishDutt! 👏 Read more 👉 [dx.doi.org/10.3748/wjg.v3…] #IBD #Cardiovascular #MetabolicSyndrome #GITwitter @VasudevanAbhi
One of the memorable highlights of my radiology sabbatical with @drgauraang in the UK — receiving an ID badge with the title “Honorary Radiologist.” 😄 Appreciated the chance to observe and learn about MRI in IBD #GITwitter #MRI
Tremendous learning experience at my first abdominal radiology conference #ESGAR2025 in Amsterdam - some incredible imaging research in the #IBD space!
Thanks @rupertleong and the #IBD team at Concord, Sydney for hosting me during my sabbatical - packed in IBD clinics, MDM, IUS, endoscopy! Incredible learning experience - highly encourage everyone to consider spending time at neighboring IBD services -same, same but different!
This 👇🏼
A trainee asked me yesterday about my recipe for success Told him that for all the 'successes' there may also be many failures... yes many.. exam failures, papers rejected, all sorts of failures! Find a mentor who will nuture, help & support you through both success & failures
Our article on protocolising care through medical and surgical treatment for fistulising Crohn's disease demonstrates that targeting different stages of disease is important➡️⬆️radiologic healing in 25%. Thanks to patients and our team. academic.oup.com/ecco-jcc/advan… @ANZIBDC
Really interesting - steroid co-therapy may not be needed with UPA - some evidence to support anecdote - useful in patients with a hx of steroid induced AEs.
Should steroids be used with upadacitinib during induction in UC? - post-hoc analysis suggests not - no impact on weeks 8 & 52 outcomes (Adapted Mayo Score) - steroid use a/w serious infections
Great opening session at AGW with live demos and talks on using intestinal ultrasound in IBD and functional gut disorders. Thanks to all our speakers and those doing the live scans!
What great night and kick off #AGW2024! Well done to the #YoungGESA team!
🌟 Tonight, #YoungGESA truly lit up the night—literally and figuratively! ✨ In our biggest event yet, the rooftop bar was packed with mentors and mentees, all sharing their light to guide each other through the journey. 💡 Remember, no matter where you are in your career, you…
Narrative review explores how to manage use of DOACs—apixaban, rivaroxaban, edoxaban, and dabigatran—in patients undergoing surgical and nonsurgical procedures to decrease risks of bleeding and thromboembolism. ja.ma/3AXfhwV
Congrats to my friends and colleagues @DrMattChoy @DrChrisLi & the PREDICT-UC team!
New research - Choy et al Intensified versus standard dose infliximab induction therapy for steroid-refractory acute severe ulcerative colitis (PREDICT-UC): an open-label, multicentre, randomised controlled trial thelancet.com/journals/langa… #IBD #GITwitter @DrMattChoy @DrChrisLi
This PK simulation study highlights the potential of using post-intensification infliximab trough thresholds associated with treatment targets in IBD to guide infliximab dose intensification strategy. #inflammatoryboweldisease #infliximab #OpenAccess bit.ly/3XgFe33
What is the optimum dose intensification strategy for infliximab following low trough levels- check out our simulation study below Led by the brilliant @Gastro_Ash With @VasudevanAbhi et al (not on twitter) link.springer.com/article/10.100…
It was great to be a part of the @GENIUS_health1 Part 2 Training Module on the Gold Coast #IUS.
#GENIUS Part 2 on the #GoldCoast was electric! ⚡️ Trainers & trainees from AUS, NZ, Korea, HK, & SG came together to master #IntestinalUltrasound. Huge thanks to everyone who joined & to our awesome sponsors—@pfizer, @abbvie, @ParagonCare/#Samsung, @Philips and @Canon.…