Finn K. Hansen

@FKH_Lab

Professor of Pharmaceutical Chemistry at University of Bonn, Germany. Vice speaker of @GRK2873.

Bonn, Deutschland

Joined March 2018

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Let´s continue our E3 ligase hopping party! Second stop: DCAF11. The switch from a CRBN to a DCAF11 recruiter converts a selective HDAC6 PROTAC into a pan-degrader. Congrats to first author Felix @fellerflix and my coworkers Heiko, Martina, Irina & Maria! go.shr.lc/3C1jgcA

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Finn K. Hansen@FKH_Lab · Oct 23

Let´s get the E3 ligase hopping party started with our first stop: FEM1B! Huge congrats to Felix for leading this project from start to finish, and shoutout to Irina, Martina, Heiko, Svenja, and Maria for their amazing contributions! 💪👏 @fellerflix - go.shr.lc/3Ykeyh2

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Finn K. Hansen Retweeted

Guillaume Laconde@Glaconde34 · Jul 18

Enhancing Solubility in VHL-Based PROTACs: Optimized USP7 Degraders for Improved Developability | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

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Finn K. Hansen@FKH_Lab · Jul 11

The University of Bonn offers two PhD scholarship financed by the DAAD within the DAAD-GSSP Programme. The PhD students will be associated to the Research Training Group RTG/GRK 2873 @grk2873 Apply now! Please RT. grk2873.uni-bonn.de/en/training-pr…

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Finn K. Hansen@FKH_Lab · Jun 19

Happy to see our dual HDAC6/10 #PROTAC paper out in #JMedChem. I am extremely proud of my PhD student Shiyang @Vincent_SYZ for making this possible. Huge thanks to all collaborators and co-workers for their amazing contributions! pubs.acs.org/doi/10.1021/ac…

FKH_Lab's tweet card. Proteolysis-targeting chimeras (PROTACs) are emerging new therapeutic modalities that facilitate the targeted degradation of disease-relevant proteins via an event-driven mode of action. In this...

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Finn K. Hansen@FKH_Lab · Apr 11

Thrilled to see Our FerroTac story is now out at @J_A_C_S - Huge congrats 🙌🏻 🥳 @ales_salerno Lianne and Claudia! @UoDCeTPD

JJ. Am. Chem. Soc.@J_A_C_S · Apr 10

Rational Design of PROTAC Linkers Featuring Ferrocene as a Molecular Hinge to Enable Dynamic Conformational Changes | Journal of the American Chemical Society @alessiociulli @Dundeeuni @UoDCeTPD. @AmphistaThera pubs.acs.org/doi/10.1021/ja…

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Finn K. Hansen Retweeted

Chemistry Europe@ChemEurope · Mar 25

#ChemMedChem Replacing a Cereblon Ligand by a DDB1 and CUL4 Associated Factor 11 (DCAF11) Recruiter Converts a Selective Histone Deacetylase 6 PROTAC into a Pan-Degrader (Finn K. Hansen and co-workers) #openaccess 🔓 onlinelibrary.wiley.com/doi/10.1002/cm…

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Finn K. Hansen@FKH_Lab · Mar 25

Happy to share the final version of our DCAF11-recruiting #HDAC #PROTAC paper. Congrats to my co-workers Felix @fellerflix, Heiko, Martina, Irina and Maria! …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cm…

FKH_Lab's tweet card. This study introduced DCAF11 as an E3 ligase for PROTAC-mediated histone deacetylase (HDAC) degradation. By replacing cereblon with DCAF11 as recruited E3 ligase, a selective HDAC6 degrader (A6) was...

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Finn K. Hansen@FKH_Lab · Feb 20

The next chapter of our HDAC #PROTAC story: CRBN-recruiting PROTACs based on a non-selective ethylhydrazide #HDAC warhead induce selective HDAC6 degradation. Congrats to my PhD students Daniel @danicious & Irina (co-first authors), and Felix @fellerflix. pubs.acs.org/doi/full/10.10…

FKH_Lab's tweet card. Histone deacetylases (HDACs) are promising targets for epigenetic drug discovery. Additionally, targeted degradation of HDACs has emerged as a novel approach in medicinal chemistry and chemical...

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Finn K. Hansen@FKH_Lab · Feb 14

Thrilled to share our #JMedChem paper dealing with DS-103! The ethylhydrazide DS-103 fully reverses cisplatin resistance and binds to HDAC6 in a manner similar to a hydroxamate. Huge congrats to first authors Daniel @danicious & Lukas and the entire team! pubs.acs.org/doi/10.1021/ac…

FKH_Lab's tweet card. In this work, we synthesized a series of peptoid-based histone deacetylase (HDAC) inhibitors with variations in the linker region and zinc-binding groups. All compounds were investigated for their...

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Finn K. Hansen@FKH_Lab · Feb 12

Happy to share our latest paper in #JMedChem on improved antagonists targeting the intracellular allosteric binding site of CCR7! Huge thanks and congratulations to the whole team for the incredible teamwork! pubs.acs.org/doi/10.1021/ac…

FKH_Lab's tweet card. Intracellular ligands of G protein-coupled receptors (GPCRs) are gaining significant interest in drug discovery. Here, we report the development of the fluorescent ligand Mz437 (4) targeting the CC...

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Finn K. Hansen@FKH_Lab · Feb 7

Excited to share our latest publication on #HDAC inhibitor-based multineurotarget drugs as a potential treatment option for Alzheimer´s disease, now online in ACS Pharmacology & TS! 🎉 Huge congrats to our amazing team and collaborators! pubs.acs.org/doi/full/10.10…

FKH_Lab's tweet card. In this work, we designed, synthesized, and evaluated two types of multineurotargeting compounds using a pharmacophore merging strategy, aiming to develop potential treatments for Alzheimer’s...

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Finn K. Hansen@FKH_Lab · Jan 16

New #PROTAC preprint: In this work, we utilized a non-selective ethyl hydrazide warhead for the selective HDAC6 degradation. Congratulations to co-first authors Daniel @danicious & Irina as well as Felix @fellerflix ! go.shr.lc/4jinjC0

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Finn K. Hansen@FKH_Lab · Jan 13

Kicking of the new year with our first publication: Our paper dealing with FEM1B-recruiting HDAC #PROTACs is online in #JMedChem @ACSBioMed. We noticed selective HDAC1-3 degradation. Congrats to Felix @fellerflix, Irina, Martina, Heiko, Svenja and Maria! pubs.acs.org/doi/10.1021/ac…

FKH_Lab's tweet card. Targeted protein degradation (TPD) represents a promising alternative to conventional occupancy-driven protein inhibition. Despite the existence of more than 600 E3 ligases in the human proteome, so...

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Finn K. Hansen@FKH_Lab · Jan 11

The application period for the second cohort of our RTG 2873 @grk2873 is open! We are now recruiting 12 PhD students. For more information see our homepage: grk2873.uni-bonn.de/en. My own project will focus on the development of HDAC #PROTACs. Please RT! grk2873.uni-bonn.de/en/training-pr…

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Finn K. Hansen@FKH_Lab · Dec 9

Check out our latest preprint on #PHOTACs: Light-activatable PHOTACs enable the optical control of targeted HDAC6 degradation. Huge congrats to Silas @WurnigSilas , Maria, Shiyang @Vincent_SYZ , and our amazing collaborators in the Nowak lab @RPNowak ! go.shr.lc/3ZudhVq

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Finn K. Hansen@FKH_Lab · Nov 17

Happy to announce that our paper on the multicomponent synthesis of quisinostat analogs as anticancer and antiplasmodial #HDAC inhibitors has been published. Congratulations to first author Daniel @danicious and all co-workers and collaborators involved! sciencedirect.com/science/articl…

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Finn K. Hansen Retweeted

Bahaa Elgendy بهاء الجندي@ElgendyBE · Nov 2

I stood in line for 3 hours to vote today! 🇺🇸 It’s a small price to pay for democracy and our right to have a voice. Voting is more than a duty; it’s a privilege. Let’s participate, make our voices heard, and respect the outcome, whatever it may be.

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Finn K. Hansen@FKH_Lab · Nov 2

Very interesting paper written by two young superstars!

CCarlos Moreno-Yruela@CarlosMYruela · Nov 1

Inhibitors of histone deacetylases (#HDACs) have longer and longer on-target residence times, which may help future clinical applications. How is this achieved? Check out our new #OpenAccess Perspective @JACS_Au, with @DrYasirRaouf, to know more! 👇🏻 pubs.acs.org/doi/full/10.10…

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Finn K. Hansen Retweeted

Chemistry Europe@ChemEurope · Oct 18

#ChemMedChem #OnTheCover A NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6, CXCR1 (Matthias Schiedel and co-workers) onlinelibrary.wiley.com/doi/10.1002/cm… @FKH_Lab @MatthiasSchied2 onlinelibrary.wiley.com/doi/10.1002/cm…

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