Exciting Instruments

Hello to all who's left ;-) We thought this may be a good time to re-introduce ourselves! We are a growing team of scientists and engineers spun out of Dr. Tim Craggs’ research lab (@Craggs_Lab) with a mission of simplifying single molecule spectroscopy to enable the broadest…

🇩🇪 Who's heading to EMBL's Gene Regulation: One Molecule at a Time conference tomorrow? We'll be there ready to chat about how single-molecule FRET, FCS, and FCCS are reshaping our understanding of molecular behaviour - one molecule at a time. Plus, see how we're making these…

🙌 So last Thursday we did something extremely EXCITING - we launched our brilliant new office and lab facility here at Pennine Five // Iconic Sheffield Offices in the heart of Sheffield and right in the middle of the Innovation Spine. This exciting chapter in our growth has…

🙌 We're still on a high from celebrating the grand opening of our combined office and lab space here at @penninefive a couple of weeks ago. It's brilliant to be neighbours with fellow innovators @FourJawMA and Phlux Technology, as we sit perfectly placed in the middle of…

Have you felt frustrated by the limited information that static structures offer? Single-molecule techniques shift the paradigm by resolving real-time dynamics, transient interactions, and molecular heterogeneity - features that ensemble measurements inherently average out or…

Are you a member of the @BiophysicalSoc? If so, there's still time to vote in the 2025 elections, featuring a group of candidates that are committed to advancing the field of #Biophysics and leading the society towards a bright future. Voting closes on the 1st August 2025.…

🙌 Check out this brilliant example of our benchtop single-molecule fluorescence spectrometer in action! @chillzaa and his team have identified a new protein-sensitive riboswitch in viruses, which presents an attractive new target for antiviral drugs. Great work 👏 #smfret…

Are you running experiments where sensitivity to picomolar concentrations is critical? Listen in below as Dr Steve Quinn, University of York, explains how the EI-FLEX has transformed his research with its smFRET, FCS and FCCS capabilities. Learn more about the EI-FLEX and…

We're thrilled to be a finalist in this year's KPMG UK Tech Innovator competition! 🚀 Support UK innovation - cast your vote and help us shine! app.sli.do/event/dkwYDnL3… #techinnovatoruk #innovation #startup #biophysics

Curious to learn more about how the EI-FLEX is bringing the full power of single-molecule spectroscopy to your benchtop with minimal training or experience? Want to see our state-of-the-art, easy-to-understand software for acquisition and analysis in action? 👋 We're here at…

🔬 Are you working with single-molecule confocal microscope instruments? Check out Professor Edwin Antony below, explaining why the EI-FLEX - our single-molecule fluorescence spectrometer - has replaced most of the single-molecule confocal microscope instruments in his lab!…

Voting in the KPMG Private Enterprise Tech Innovator in the UK competition is open! Show Exciting Instruments - and Yorkshire and the North East - your support by voting below 👇 app.sli.do/event/dkwYDnL3… #innovation #startups #deeptech #yorkshire #sheffield

Thank you again to South Yorkshire's Mayor @olivercoppard for officially cutting the ribbon at our grand opening event last week, and to SYMCA for part-funding our new home. Take two minutes to watch the video below, which sums up perfectly how South Yorkshire and Exciting…

🇮🇹 Ciao - we're at #EBSA! Our Senior Application Scientist Mahmoud is on standby to demo our benchtop single-molecule fluorescence spectrometer and accompanying acquisition and analysis software! Visit us at stand 19 to find out how you can advance your research with innovative…

Forget what you think you know about single-molecule fluorescence spectrometry instruments! Introducing the EI-FLEX.... ✅ Run single-molecule FRET and FCS experiments from your lab benchtop ✅ Very easy to use, so everyone in the lab can generate data ✅ No compromise; the…

🇮🇹 The countdown to #EBSA2025 is on! We're excited to bring our expertise in single-molecule biophysics to the EBSA conference in Rome at the end of this month. Tim Craggs, Paul Wheeler and Mahmoud Abdelhamid will be on hand to discuss: → Single-molecule characterisation →…

The one-dimensional character of the dynamics between two fluorophores is a limitation of smFRET - how can adding in a third fluorophore (three-colour smFRET) and using networks of pairs of fluorophores help to overcome this? Check out Professor Thorsten Hugel's Exciting Seminar…

Great first day at #MOSBRI! Our Senior Application Scientist Mahmoud is ready and waiting to discuss your research challenges and how single-molecule fluorescence techniques like smFRET and FCS can take your work to the next level. Book a meeting with him - we’re here until…

Single-molecule researchers - do you ever feel in need of more connections, more conversations, more support and more exchanging of ideas? We wanted to create a space to facilitate all of this and more! A place for asking questions, sharing knowledge, discussing research, having…