Dermal Cell News

As the largest organ in the human body, the skin is implicated in a wide range of health conditions. 🩹 Dermal Cell News, a free newsletter offered by Science News by @STEMCELLTech is dedicated to covering it all. Subscribe here: bit.ly/4kkWMEu

A new study, published in @NatureComms, demonstrates an essential role for CFAP100 in #keratinocyte division. It shows that CFAP100 couples microtubule glutamylation to spindle pole integrity in keratinocytes to promote epidermal development. go.nature.com/46rKp55

Mitochondria-driven pseudohypoxic induction is critical for sustaining HIF1 signaling in metastasizing #melanoma cancer cells and can be exploited to develop anti-metastatic therapies, report Dr. Byoung Heon Kang and team. 📝: go.nature.com/41d65OV | @sigtrans_sttt

Investigators highlight the role of DGAT2 and lipid metabolism in the pathogenesis of #psoriasis and reveal their interaction with immune responses in psoriasis. 💡 A deep dive in @JCI_insight: bit.ly/3TXey4X

This review discusses what is known about the genetics of #acne, and what it teaches us about the pathogenesis of this common skin disorder. 🔎 Give it a read: bit.ly/4f8KPzN

In this lebrikizumab study in patients with skin of color and moderate-to-severe #AtopicDermatitis (AD), lebrikizumab improved signs and symptoms of AD and confirmed its favorable safety profile. Dig into the findings: bit.ly/4kTY34H

This research showed that lactic acid could promote protein lactylation in a dose-dependent manner in #melanoma cells. 👉 Lactic acid could significantly reduce melanin synthesis both in vitro and in vivo. go.nature.com/3GWs2uQ

This story outlines mechanisms driving resistance to anti-PD-1 therapy, including both tumor-intrinsic and tumor-extrinsic factors, and discuss biomarkers relevant to clinical practice in #melanoma. 📚 Give it a read: bit.ly/4kQ2eP5

Scientists from @penn_state generated immortalized primary mouse keratinocytes inducibly expressing multiple engineered and cancer-associated mutations, including those present in non-#melanoma skin cancers. 🧫 🔗 bit.ly/44yplZt

Researchers reported a novel long noncoding RNA, LINC00622, that modulates mTORC1-regulated autophagy in cutaneous #melanoma. 💀 go.nature.com/3GMNWAF

Melasma is a recurrent and treatment-resistant hyperpigmentation disorder. 💭 In this study, scientists establish a stable, reproducible, and clinically relevant mouse model of melasma. Check it out: bit.ly/3Iu1TUI

Male pattern androgenetic #alopecia is a physiological phenomenon in which defined hair follicle populations in developmentally preprogrammed scalp skin regions undergo a reversible (mini-)organ transformation in predisposed individuals. 🔎: bit.ly/4kGPHx8

#Oxyresveratrol, a natural derivative of resveratrol, has been shown to possess antimelanogenic properties. A new study investigates the effects and mechanisms of oxyresveratrol on melanogenesis, dendrite formation, and melanosome transport. Read the @SciReports study:…

Check out this #review from the lab of Dr. René Rossi at @Empa_CH! 👇 It presents the fundamental optical properties of #HumanSkin and outlines the principles and materials used to replicate these properties, including absorbers, scatterers, and matrix materials. 🔗…

A new study from researchers at Chongqing University reveals two novel signaling mechanisms that shape #melanocyte adaptive patterning and highlight the #HairFollicle as a regulatory hub for melanocyte physiological behaviors. 🗒️ Learn more: bit.ly/40MwAun

The limited regenerative capacity of epidermal cells following tissue injury impairs wound healing in #DiabeticFootUlcers. 🦶 Researchers have developed a safe, efficient, and clinically translatable strategy for #SkinRegeneration via direct lineage reprogramming.…

Candida auris conserved adhesin, Als4112, is required for skin colonization via #keratinocyte attachment and direct interactions with host ECM proteins, reported Dr. Teresa O'Meara and team. 🥼 @NatureComms | go.nature.com/4exrfgh

A @UZH_en team identified a regulation at the RNA level and identified miR-34a-5p as a novel positive regulator of NLRP1 mRNA expression in human #keratinocytes and squamous cell carcinoma cells downstream of p62 mRNA. 👉 go.nature.com/44rOaF6

Scientists showed that CDKL3 promoted malignant #melanoma progression via targeting autophagy related 5 (ATG5). CDKL3 induced melanoma cell autophagy through an ATG5-dependent manner. 💡Learn more: bit.ly/40BOxM6

A research group from Zhejiang University identified RIPK4 as an alternative upstream kinase of LATS1/2 in the Hippo pathway through screening a kinome library. ✅ Check out their study! bit.ly/3Tizraw

Dr. Embregts and team at @ErasmusMC investigated the involvement of epidermal #keratinocytes in rabies virus entry. 🚪 🦠 More details here: go.nature.com/45J00Ns