Bisrat Debeb
@Debeblab
Associate Professor @MDAndersonNews - investigating Inflammatory breast cancer (IBC) and brain metastasis. Tweets are my own. RTs not endorsements.
Excited to share our latest pre-print “Soluble E-cadherin Drives Brain Metastasis in Inflammatory Breast Cancer” led by the outstanding Xiaoding Hu, an instructor in my lab. #Breastcancer #Brainmetastasis #IBC #Ecadherin #ReactiveAstrocytes #CXCR2 👉 biorxiv.org/content/10.110…
A major technological advancement that opens up an entirely new area of cell biology ... @nature reports a versatile platform for high-throughput functional interrogation of RNA localization in living cells and organisms. doi.org/10.1038/s41586…
I cannot stress this enough: pairing a 4% funding line with the largest cut in NCI history will devastate the future of cancer research - and patients. We would be turning our backs on decades of progress.
bioRxiv has a dedicated section for negative results. Use it. Share negative results. Your colleagues will appreciate it.
A potent and specific NNMT inhibitor that reduces the tumor burden & metastasis while enhancing checkpoint blockade efficacy in multiple mouse cancer models by inhibiting cancer fibroblast recruitment of MDSCs nature.com/articles/s4158… @Nature @ErnstLengyel
Established Investigators need to rank in the 4th percentile, whereas Early Investigators need to be in the 10th percentile. This means that among 80 reviews in a study section, only 3 will be below the 4th percentile. cancer.gov/grants-trainin…
This is our why: #research to improve the lives of people living with #MetastaticBreastCancer!
Huge thanks to our collaborators and funders - DoD, @metavivor, @Americancancer, @NIH/NCI … And big congrats to Xiaoding Hu for leading this impactful work!👏👏👏@MDAndersonNews
🚨Today, in @NatureCancer, we show that CAR-T cells and CAR-NK cells contain the seeds of their own self-destruction. Disruption of a FAS-L/FAS circuit enhances CAR potency against liquid and solid cancers. rdcu.be/exjEy @MSKCancerCenter @parkerici @MSK_DeptOfMed
Understanding and reversing mammary tumor-driven reprogramming of myelopoiesis to reduce metastatic spread dlvr.it/TLx7DZ
Brain metastasis: From etiology to ecotypes dlvr.it/TLxJTF
ZEB2 is a master switch controlling the tumor-associated macrophage program dlvr.it/TLwFvT
Kudos to the international team from 🇨🇳 & 🇺🇸 that conducted this important study published in @Cancer_Cell Brain metastases are one of most dreaded complications of advanced disease. Pan-cancer human brain metastases atlas at single-cell resolution cell.com/cancer-cell/ab…
Pan-cancer human brain metastases atlas at single-cell resolution dlvr.it/TLw4ZN
Super excited to share our newest piece out today @NatureRevCancer linking age-induced metabolic reprogramming to cancer development. nature.com/articles/s4156…
“A dream come true”: A child walks again after breakthrough treatment for a rare genetic disorder—thanks in part to NIH-funded research. Scientists at @nyulangone discovered that a CoQ10 precursor can help brain cells restore energy production, offering new hope for families…
Weight loss provides far more benefit than just losing fat @Nature @NatureNV nature.com/articles/s4158… nature.com/articles/d4158…
A new way to get very early detection of colon cancer using cell-free RNA (instead of DNA) @NatureBiotech nature.com/articles/s4158…
And today's @latimes coverage, by @niamh_ordner latimes.com/science/story/…
Summary Table of the massive defunding of biomedical research in the United States nytimes.com/interactive/20…
📢 Now live at @Nature Our team discovered that PPP2R1A mutations are linked to improved response to immunotherapy in ovarian clear cell carcinoma. @Yibo_Dai @AmirJazaeri @ZhangLabMDA @MDAndersonNews nature.com/articles/s4158…
Online Now: Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps dlvr.it/TLjsMp