Olson Lab
@DEOlsonLab
We develop plasticity-promoting neurotherapeutics through a combination of chemistry, molecular/cellular biology, and behavioral neuropharmacology.
I love all of our papers equally, but I might love this one a bit more. Rare to see complex molecule total synthesis, molecular neuroscience, and behavioral neuropharmacology in the same paper! Thanks to everyone who helped make this work possible pnas.org/doi/10.1073/pn…
Check out our ibogaine total synthesis in @NatureChemistry! This was a tough project that took nearly a decade to complete by @UCDavisIPN researchers. Includes the synthesis of the unnatural enantiomer of ibogaine and ibogaine analogues that modulate SERT nature.com/articles/s4155…
Exciting new research in @ScienceMagazine from the labs of IPN researchers @tinakim_neuro @DEOlsonLab reveals that the neural circuitry mediating the anti-anxiety and hallucinogenic effects of #psychedelics are distinct. @UCDavisCNS @UCDLandS @UCDavisMed science.org/doi/10.1126/sc…
Check out our latest collaboration in @ScienceMagazine Magazine with @tinakim_neuro's lab, where we re-activate psychedelic-responsive neurons to induce an anxiolytic effect without a head-twitch response. science.org/doi/10.1126/sc…
Exciting news! We've launched a crowdfunding campaign for a new art installation in the Chemistry Building! 🎨 Help us raise $5,000 for the amazing artists! Every contribution and share counts. Let’s create something extraordinary! 🙌💙 Join us: shorturl.at/jL8rb
IPN faculty affiliate @tinakim_neuro and team just published in @naturemethods about a protein-based tool expected to aid in identifying how #psychedelics impact brain disorders by tagging neurons activated by psychedelics. nature.com/articles/s4159…
Check out our latest collaboration with Christina Kim's Lab in Nature Methods: nature.com/articles/s4159… The number of neurons tagged with CaST in the PFC following psilocybin administration correlated with head-twitch response, but the number of cfos tagged neurons did not.
The newest research from IPN Director @DEOlsonLab and team suggests that tropane analogs can promote #neuroplasticity with fewer side effects than compounds like scopolamine. Read more here: pubs.acs.org/doi/10.1021/ac…
Check out the latest IPN paper in J. Med. Chem. on the development of psychoplastogenic DYRK1A inhibitors with potential for treating Alzheimer's disease especially early-onset Alzheimer's disease associated with Down Syndrome pubs.acs.org/doi/10.1021/ac….
@UCDavisIPN Director @DEOlsonLab talks about psychedelics and nonhallucinogenic psychoplastogens on the @UChicago's Big Brains podcast news.uchicago.edu/psychedelics-w…
IPN director @DEOlsonLab was interviewed for this PNAS news feature on the mechanisms of psychedelics pnas.org/doi/10.1073/pn…
Within #psychedelic science, the debate lingers: Is it mind-blowing experiences or powerful #molecules that spur change? Join @TTBOOK to hear David E. Olson's take. Also available on @Spotify! youtu.be/JunhDmkrM88?si…
The @UCDavisIPN will be sending out their first newsletter soon. If you are interested in #psychedelics or #neurotherapeutics and would like to receive a copy, please sign up by clicking on the link on this page: neurotherapeutics.ucdavis.edu/news-1
Congrats to the Delix team on their positive phase 1 results that they are presenting at ACNP! Also, super excited that Jeff Jonas, former CEO/CIO of Sage Therapeutics, will be joining the Delix SAB! businesswire.com/news/home/2023…
nice article featuring @UCDavisIPN associate director @johnalangray cleveland.com/news/2023/11/a…
article in @TheAtlantic on nonhallucinogenic psychoplastogens: theatlantic.com/health/archive…
our latest review covering the effects of psychedelics on neuronal physiology: annualreviews.org/doi/abs/10.114…
great article by @Sara_Reardon in @Nature about the therapeutic mechanisms of #psychedelics nature.com/articles/d4158…
very interesting article about the role of neuroplasticity in treating depression: wired.com/story/why-anti… Covers a nice @molpsychiatry paper from Gitte Knudsen's group
