Clinical & Translational Immunology

@ClinTransImmuno

Open access journal publishing cutting-edge advances in biomedical research for scientists and physicians. Official journal of @ASImmunology #ClinTransImmunol

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Joined March 2020

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Clinical & Translational Immunology@ClinTransImmuno · Feb 3, 2021

📢Announcing the launch of our COVID-19 Collection. Covering original research, reviews & much more. Check it out now 👇onlinelibrary.wiley.com/page/journal/2… #ClinTransImmunol #CTICOVIDCollection #SARSCoV2 #COVID19 #COVID_19 #Immunology #Openaccess @wileymolecular @khanna_rajiv @ASImmunology

ClinTransImmuno's tweet image. 📢Announcing the launch of our COVID-19 Collection. Covering original research, reviews &amp; much more. Check it out now 👇onlinelibrary.wiley.com/page/journal/2… #ClinTransImmunol #CTICOVIDCollection #SARSCoV2 #COVID19 #COVID_19 #Immunology #Openaccess @wileymolecular @khanna_rajiv @ASImmunology

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Clinical & Translational Immunology@ClinTransImmuno · May 13

IgG aggravates TNF-α-mediated osteoclastogenesis by enhancing TNFR1/NF-κB signaling, helping explain the greater joint damage seen in RA compared to SLE. @ASImmunology @WileyGlobal onlinelibrary.wiley.com/doi/full/10.10…

ClinTransImmuno's tweet card. This study uncovered a previously unrecognised dual role of IgG in osteoclastogenesis: while it suppressed receptor activator of nuclear factor kappa-B ligand (RANKL)-dependent osteoclast formation,...

Clinical & Translational Immunology@ClinTransImmuno · Jul 13

In t(8;21) AML, leukemic arrest at monocytic stages predicts poorer survival and higher relapse, highlighting differentiation stage as a key prognostic factor beyond genetics. @ASImmunology @WileyGlobal onlinelibrary.wiley.com/doi/10.1002/ct…

ClinTransImmuno's tweet card. In this multi-centre study of 338 t(8;21) acute myeloid leukaemia patients, we demonstrate that leukaemic arrest at monocytic differentiation stages (Immuno-Mono) predicts significantly worse 2-year...

Clinical & Translational Immunology@ClinTransImmuno · Jul 13

Combined maintenance with anti-PD-1 and capecitabine significantly improves progression-free survival in metastatic nasopharyngeal carcinoma, offering a promising strategy post-chemotherapy. @ASImmunology @WileyGlobal onlinelibrary.wiley.com/doi/10.1002/ct…

Clinical & Translational Immunology@ClinTransImmuno · Jul 13

Post-COVID-19 patients show long-term immune alterations across cell types, with potential links to BCG vaccination and improved outcomes in COVID-19 and sepsis. @ASImmunology @WileyGlobal onlinelibrary.wiley.com/doi/10.1002/ct…

ClinTransImmuno's tweet card. This study examined long-term immune alterations in individuals who recovered from COVID-19 and explored potential links between Bacillus Calmette–Guérin (BCG) vaccination, latent infections and...

Clinical & Translational Immunology@ClinTransImmuno · Jul 13

Acute high-intensity exercise boosts circulating CD8+ T cells with enhanced cytotoxicity and metabolic rewiring, suggesting improved immune surveillance post-HIIT. @ASImmunology @WileyGlobal onlinelibrary.wiley.com/doi/10.1002/ct…

Clinical & Translational Immunology@ClinTransImmuno · Jul 13

Trauma reshapes circulating dendritic cell and monocyte subsets, with distinct regulation of adhesion GPCRs EMR2, CD97, and EMR3 revealing diverse immune roles in injury response @ASImmunology @WileyGlobal onlinelibrary.wiley.com/doi/10.1002/ct…

ClinTransImmuno's tweet card. We monitored various dendritic cell (DC) and monocyte subsets in traumatised patients for up to 240 h after injury, and compared them with uninjured volunteers who underwent the same blood sampling...

Clinical & Translational Immunology Retweeted

Rajiv Khanna@khanna_rajiv · Jul 9

Join us for celebration of 25 years of Brisbane Immunology Group (BIG). BIG-2025 retreat will be held at @seaworldresort Please register here shorturl.at/7AoTo @QIMRB_Institute @ClinTransImmuno @UQ_News @MaterResearch @qldhealth @YUmmunology @UQMedicine @HealthTQld

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Clinical & Translational Immunology@ClinTransImmuno · Jun 12

Allogeneic SARS-CoV-2-specific T-cell therapy was safe and reduced viral load in most immunocompromised cancer patients with COVID-19 in a phase I trial. @WileyGlobal @ASImmunology onlinelibrary.wiley.com/doi/10.1002/ct…

ClinTransImmuno's tweet card. In this study, we conducted an open-label phase I trial to assess the feasibility and safety of allogeneic SARS-CoV-2 specific T cells in immune-compromised cancer patients with COVID-19. Our...

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Clinical & Translational Immunology@ClinTransImmuno · Jun 7

Tattoo uveitis shares key inflammatory features with sarcoidosis but is antigenically distinct—highlighting CXCR5 downregulation and EMT signatures as hallmarks of active sterile granulomatous disease. @ASImmunology @WileyGlobal onlinelibrary.wiley.com/doi/10.1002/ct…

ClinTransImmuno's tweet card. Tattoo uveitis (TU) resembles sarcoidosis but is distinguished by the absence of systemic lymphadenopathy despite inflammation of skin and eyes. In this study, we compared blood-borne signatures of...

Clinical & Translational Immunology@ClinTransImmuno · Jun 7

A new study shows semi-automated CAR T-cell manufacturing using Cellmation software delivers high-quality, functional cells—offering a scalable, efficient alternative to manual production. @ASImmunology @WileyGlobal onlinelibrary.wiley.com/doi/10.1002/ct…

ClinTransImmuno's tweet card. We present an end-to-end methodology for semi-automating the cell therapy manufacturing workflow using CTS Cellmation software – an off-the-shelf software solution – to control physically connected...

Clinical & Translational Immunology@ClinTransImmuno · Jun 1

Public scRNA-seq data are key to paediatric cancer research, but poor deposition standards hinder reuse. A review of >1.3M cells from 488 samples proposes a framework to improve practices. onlinelibrary.wiley.com/doi/10.1002/ct… @ASImmunology @WileyGlobal

ClinTransImmuno's tweet card. Publicly available scRNA-seq data can support new research ideas, especially in resource-limited settings, but the lack of standards complicates data validation and analysis. In this article, we...

Clinical & Translational Immunology@ClinTransImmuno · Jun 1

Lower B cells and Tregs—seen before transplant—were linked to chronic lung allograft dysfunction, not donor-specific antibodies. High-dimensional flow cytometry reveals early immune clues. @WileyGlobal @ASImmunology onlinelibrary.wiley.com/doi/10.1002/ct…

Clinical & Translational Immunology@ClinTransImmuno · May 18

In posterior uveitis, vitreous T cells—especially polyfunctional CD8+ cells—show distinct, antigen-specific responses not mirrored in blood, highlighting the limitations of PBMCs in reflecting ocular immunity. @ASImmunology @WileyGlobal onlinelibrary.wiley.com/doi/10.1002/ct…

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Clinical & Translational Immunology@ClinTransImmuno · May 13

T-cell responses to SARS-CoV-2 spike differ after vaccination vs. natural infection—vaccines focus on limited regions and HLA-A, while infection broadens epitope spread and shifts to HLA-B (esp. B7) @ASImmunology @WileyGlobal onlinelibrary.wiley.com/doi/full/10.10…

ClinTransImmuno's tweet card. We investigated the immunoreactivity of SARS-CoV-2 spike protein T-cell epitopes in individuals who were SARS-CoV-2 naive, vaccinated with the AstraZeneca vaccine, and those who became naturally...

Clinical & Translational Immunology@ClinTransImmuno · Apr 13

Radiotherapy can boost T-cell responses and enhance immunotherapy, but clinical success remains limited—future research must address barriers and optimize combinations for better cancer outcomes @ASImmunology @WileyGlobal onlinelibrary.wiley.com/doi/full/10.10…

ClinTransImmuno's tweet card. While immune checkpoint inhibitors have shown remarkable success in solid tumours, the induction of T cell dysfunction limits their effectiveness, resulting in treatment resistance and relapse. This...

Clinical & Translational Immunology@ClinTransImmuno · Mar 25

Progressive loss and activation of MAIT cells correlate with worsening myocardial ischaemia and remodelling in CAD patients, possibly due to gut microbial leakage @ASImmunology @WileyGlobal onlinelibrary.wiley.com/doi/full/10.10…

Clinical & Translational Immunology Retweeted

Australian and New Zealand Society for Immunology@ASImmunology · Mar 8

We warmly congratulate Dr Charis Teh - winner of the Margaret Baird Women in Immunology ASI Award!! @WEHI_research #IWD25 Read more here: immunology.org.au/blogs/Latest-N…

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Clinical & Translational Immunology@ClinTransImmuno · Mar 8

Long-term γδ T cell reconstitution after allogeneic stem cell transplantation shows a normalised repertoire, sustained CMV control, and increased activated Vδ1+ T cells in severe chronic GVHD @ASImmunology @WileyGlobal onlinelibrary.wiley.com/doi/full/10.10…

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Clinical & Translational Immunology@ClinTransImmuno · Mar 6

MAIT cell activation profiles in the emergency department distinguish sepsis severity, with high CD69 expression linked to worse outcomes and cytokine-driven activation @ASImmunology @WileyGlobal onlinelibrary.wiley.com/doi/full/10.10…

ClinTransImmuno's tweet card. In this study, mucosal-associated invariant T (MAIT) cell characteristics were evaluated in blood from patients who triggered a clinical sepsis alert at the emergency department. High-dimensional...

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Clinical & Translational Immunology@ClinTransImmuno · Mar 6

Lower dendritic cell levels in blood and airways predict severe COVID19, while monocytes accumulate in the lower airways. DC depletion persists in severe cases, but most immune responses recover post-infection @ASImmunology @WileyGlobal onlinelibrary.wiley.com/doi/full/10.10…

ClinTransImmuno's tweet card. By analysing 147 COVID-19 patients with different level of disease severity using flow cytometry, functional assays and proteomics, we found that severe COVID-19 is marked by a significant decrease...

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