Caleb Lareau
@CalebLareau
Assistant Professor at Memorial Sloan Kettering. Interested in computational and translational immunology. crazy cat guy. Same handle at the new place 🦋
When I decided to move across the country to do my postdoc with @Satpathology, I knew he was a one-in-a-billion kind of guy. Single-cell sequencing just confirmed it--Check out what the most serendipitous discovery of my career! (PS my mitos are super boring 👎👎)
I am a strong believer that depth of data can be just as powerful as scale of data. Deep analysis of small groups of humans, and even individuals, can lead to novel biological insights and principles. Today I am the guinea pig. In my own blood, @CalebLareau finds strong evidence…
*New Open-Access Long Read Resource*. We sequenced 1,019 genomes from the 1000 Genomes Project sample cohort using @nanopore. Sequencing data is available at bit.ly/4m8dlE2. @embl @HHU_de @IMPvienna @CRGenomica nature.com/articles/s4158… [1/8]
I am a strong believer that depth of data can be just as powerful as scale of data. Deep analysis of small groups of humans, and even individuals, can lead to novel biological insights and principles. Today I am the guinea pig. In my own blood, @CalebLareau finds strong evidence…
🚨Today, in @NatureCancer, we show that CAR-T cells and CAR-NK cells contain the seeds of their own self-destruction. Disruption of a FAS-L/FAS circuit enhances CAR potency against liquid and solid cancers. rdcu.be/exjEy @MSKCancerCenter @parkerici @MSK_DeptOfMed
Am full time with the Blazers starting this season (remote in DC for now). I am *so* excited for the team we have both on and off the court. I cannot wait for the season to start.
🎉 Congratulations to #MSKPostdoc @PaulKlauser, mentored by @LewisLabMSKCC & @CalebLareau, on being awarded the prestigious @DamonRunyon Quantitative Biology Fellowship! 👏 damonrunyon.org/news/entries/8…
Out today in @Nature our study of long-lived T cell responses to personalized neoantigen vaccines in #PDAC led by Zach Sethna & @PabloGuasp. Read the summary below by @TheVinodLab @MSKCancerCenter 👇👇👇 nature.com/articles/s4158…
#mRNAvaccines for #PancreaticCancer (PDAC) PART4 1. Out today in @Nature nature.com/articles/s4158… 🧵👇🏽 [1/23]
🚨Today in @Nature, we show that mRNA mis-splicing creates clonal public neoantigens in solid cancers. An amazing collaboration between @UCSFCancer and @MSKCancerCenter driven by @DarwinKwok1 and co-led by Hideho Okada, @josephcostell14 and @KlebanoffLab. nature.com/articles/s4158…
MSK researchers are key contributors in a project called The Human Virome Program, which seeks to map the landscape of viruses in our bodies and to help analyze the impact they have on human health and disease. Learn more about MSK's @CalebLareau and his team's exciting research:…
An unexpected (and clever) combination of fixed-cell scRNA-seq and rna-based cell sorting. How cool! Could this replace some FACS-based workflows? Opens up possibilities for interrogating specific nuclei from frozen and ffpe tissues …
PERFF-seq is out today in @NatureGenet! Our recent thread summarizes why we are excited about the prospects of programmable nucleic acid cytometry for studying rare cell states. nature.com/articles/s4158…
LY6G6D is the next DLL3
We had a productive day in Houston at the 39th Annual Meeting of #SITC24 last week, engaging with industry experts and presenting #preclinical data on LY6G6D. We appreciate everyone who visited our poster to learn more about our efforts toward advancing CB21 for MSS CRC patients.
Jon Stewart’s 2-minute history lesson here is worth everyone’s time before we start confidently breaking out our theories of what happened