CBU

@CBUuniTo

Computational Biology Unit led by Prof. Paolo Provero Neurosciences Dept. at @unito Tweets are from lab members.

Torino, Italy

Joined January 2022

155Following

94Followers

Pinned

CBU@CBUuniTo · Feb 22

Mapping the regulatory effects of common and rare non-coding variants across cellular and developmental contexts in the brain and heart biorxiv.org/content/10.110…

Pinned

CBU@CBUuniTo · Jan 14

Molecular and cellular dynamics of the developing human neocortex nature.com/articles/s4158…

CBUuniTo's tweet card. Nature - Tripotential intermediate progenitor cells are responsible for the local production of GABAergic neurons, oligodendrocyte precursor cells and astrocytes in the human neocortex.

CBU@CBUuniTo · May 26

And more posters at #eshg today! Meet Daniela and Davide at P18.116C and P21.001C in the coming session, and Roberta at P21.022D later today!

CBUuniTo's tweet image. And more posters at #eshg today! Meet Daniela and Davide at P18.116C and P21.001C in the coming session, and Roberta at P21.022D later today!

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CBU@CBUuniTo · May 25

Are you at #eshg2025 in Milan? Come and check out what we are up to! 3 posters from our group in the coming session: Camilla at P18.011.B, Irene at P18.016B and Ettore at P18.131B!

CBUuniTo's tweet image. Are you at #eshg2025 in Milan? Come and check out what we are up to! 3 posters from our group in the coming session: Camilla at P18.011.B, Irene at P18.016B and Ettore at P18.131B!

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CBU@CBUuniTo · Apr 11

Our work on the molecular basis of the genetic correlation between BMI and brain morphology has now appeared in PLOS Genetics journals.plos.org/plosgenetics/a… Thanks to @DFusco17, @CamillaMarinel8, @MathildeAndr11, @LuciaTroiani, Martina Noè, and @FabrizioPi1139

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CBU@CBUuniTo · Apr 11

Genetically regulated eRNA expression predicts chromatin contact frequency and reveals genetic mechanisms at GWAS loci nature.com/articles/s4146…

CBUuniTo's tweet card. Nature Communications - Here, the authors present trained models of genetically regulated enhancer RNA expression, finding that genetically regulated expression predicts chromatin contact frequency...

CBU@CBUuniTo · Apr 1

An atlas of single-cell eQTLs dissects autoimmune disease genes and identifies novel drug classes for treatment sciencedirect.com/science/articl…

CBU@CBUuniTo · Mar 14

biorxiv.org/content/10.110…

CBU@CBUuniTo · Feb 24

Plasma proteome variation and its genetic determinants in children and adolescents nature.com/articles/s4158…

CBUuniTo's tweet card. Nature Genetics - This mass spectrometry-based proteomic study profiles the plasma proteome in 2,147 children and adolescents and reveals its association with age, sex, puberty, body mass index and...

CBU@CBUuniTo · Feb 16

biorxiv.org/content/10.110…

CBU@CBUuniTo · Feb 12

Prioritizing effector genes at trait-associated loci using multimodal evidence nature.com/articles/s4158…

CBUuniTo's tweet card. Nature Genetics - FLAMES is a machine learning approach combining variant fine-mapping, SNP-to-gene annotations and convergence-based gene prioritization scores to identify candidate effector genes...

CBU@CBUuniTo · Feb 9

An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development cell.com/cell/fulltext/…

CBUuniTo's tweet card. Mapping transcription start sites across five mammalian species before, during, and after embryonic genome activation unveils widespread transposable element-driven transcription and co-option of...

CBU@CBUuniTo · Feb 6

Polygenic burden of short tandem repeat expansions promotes risk for Alzheimer’s disease nature.com/articles/s4146…

CBU@CBUuniTo · Jan 21

Multi-omic quantitative trait loci link tandem repeat size variation to gene regulation in human brain nature.com/articles/s4158…

CBUuniTo's tweet card. Nature Genetics - Mapping of multi-omic molecular quantitative trait loci associated with tandem repeat size variation in up to 4,412 human brain samples from 1,597 donors offers insights into how...

CBU@CBUuniTo · Jan 17

Cell state-dependent allelic effects and contextual Mendelian randomization analysis for human brain phenotypes nature.com/articles/s4158…

CBUuniTo's tweet card. Nature Genetics - Analysis of single nuclei RNA-sequencing data across eight major brain cell types identifies putative causal associations between cell-type-specific expression and brain phenotypes.

CBU@CBUuniTo · Jan 11

Cell type and dynamic state govern genetic regulation of gene expression in heterogeneous differentiating cultures: Cell Genomics cell.com/cell-genomics/…

CBUuniTo's tweet card. Popp et al. generate dozens of cell types from 53 human iPSC lines in order to characterize the dynamic genetic regulation of gene expression across early stages of cellular differentiation. Access...

CBU@CBUuniTo · Jan 8

Specificity, length, and luck: How genes are prioritized by rare and common variant association studies biorxiv.org/content/10.110…

CBU@CBUuniTo · Dec 20

nature.com/articles/s4158…

CBU@CBUuniTo · Dec 17

Neanderthal ancestry through time: Insights from genomes of ancient and present-day humans science.org/doi/10.1126/sc…

CBU@CBUuniTo · Dec 13

Structural MRI of brain similarity networks nature.com/articles/s4158…

CBUuniTo's tweet card. Nature Reviews Neuroscience - Through use of the anatomical similarity, structural MRI analytics are now enabling the network organization of individual brains to be mapped. In this Review,...