Blood Neoplasia

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Despite improvement in clinical outcomes, early progressors and patients with double-refractory disease continue to have poor outcomes. ow.ly/PInR50VVT7b #lymphoidneoplasia

🚨🚨🚨 📣We have published our 100th paper! ow.ly/tHaG50Wh38y 🎉🎉🎉

Eosinophilia is seen in both reactive and clonal processes. In acute myeloid leukemia (AML), the presence of eosinophilia often represents underlying gene rearrangements. ow.ly/vXll50VVTKz #myeloidneoplasia

Shared clonal signatures in nonmalignant B cells and T-PLL cells indicate a common clonal ancestry. ow.ly/lJI950VVTuy #lymphoidneoplasia

Short-duration infusion obinutuzumab with venetoclax in chronic lymphocytic leukemia: a prospective observational study ow.ly/fUI550VVTgk #lymphoidneoplasia

The bone marrow and peripheral blood create different microenvironments for acute myeloid leukemia cells. ow.ly/Gpx750VVT3v #myeloidneoplasia

Downregulation of IRF4 expression is the molecular basis and rationale for the anti-MM effect of RK-552. ow.ly/LgRw50VVT1w #lymphoidneoplasia

pDC-AML have a distinct immune signature compared to blastic plasmacytoid dendritic cell neoplasm with CD56low and TdThigh/CD34high expression. ow.ly/GfrQ50VVSXr #myeloidneoplasia

There are significant racial and ethnic disparities in the incidence and survival of patients with acute myeloid leukemia. ow.ly/i8Th50VVSNL #myeloidneoplasia

Combined loss of the 7q genes CUX1 and EZH2 impairs the DNA damage response, driving hematopoietic clonal expansion and drug resistance. ow.ly/jzn250VVSC3 #myeloidneoplasia

DAC/ATO was more clinically effective against MDS/AML than DAC/Carbo, absent adverse toxicity. ow.ly/BBYv50VVSzJ #clinicaltrialsandobservations

Recurrent xanthogranulomas may arise through second hits acquired by the progeny of long-lived BRAF- or KRAS-mutated multipotent progenitors. ow.ly/I1rJ50VVSxa #myeloidneoplasia

VCR dose reduction was not significantly associated with poor PFS in patients with DLBCL treated with R-CHOP, based on data from JCOG0601. ow.ly/CiGM50VVSqR #clinicaltrialsandobservations

Recurrent xanthogranulomas may arise through second hits acquired by the progeny of long-lived BRAF- or KRAS-mutated multipotent progenitors. ow.ly/y30z50VVSny #myeloideneoplasia

Disparities in leukemia mortality exist by race/ethnicity and sociodemographic factors, including rural location and proximity to providers. ow.ly/e9Gl50VVS04 #clinicaltrialsandobservations #lymphoidneoplasia

Whole-transcriptome sequencing identifies FTs with diagnostic and therapeutic significance in AML without recurrent genetic abnormalities. ow.ly/Ll7B50VVRVm #myeloidneoplasia

The addition of daratumumab to CyBorD significantly improves hematological and organ response. ow.ly/ehYa50VVRNX #clinicaltrialsandobservations

Clone size is an independent prognostic factor for OS and LFS, refining the predictive capabilities of the revised and molecular IPSS. ow.ly/WRfv50VVRIA #myeloidneoplasia

Thymic peptides in immune reconstitution and clinical outcome after allogeneic hematopoietic cell transplantation ow.ly/aUgo50VVRo7 #translationalresearch