Baran Lab
@BaranLabReads
Electrifying chemistry...
Appearing today in @ScienceMagazine : science.org/doi/10.1126/sc…
Finally, RADICAL CROSS COUPLING without the exogenous REDOX. We disclose in @ChemRxiv (chemrxiv.org/engage/chemrxi…) a broadly general platform for achieving transformations that normally required excess metallic or chemical reducing agents or photochemical setups (and their…
The first time @BRSM_blog found organic chemistry fascinating was in an undergraduate course on natural products. Amongst stories about beautiful molecules and legendary scientists who jockeyed to understand and eventually make them, he was hooked. chemistryworld.com/opinion/--bipi…
Appearing today in @J_A_C_S : pubs.acs.org/doi/full/10.10…
TEN STEPS TO A MARINE TREASURE: Gram-Scale Synthesis of Bipinnatin J – featuring methods that weren't known ≅3 years ago to forge 3 key C–C bonds... Appearing today in @ChemRxiv (chemrxiv.org/engage/chemrxi…). Quick Summary: A concise, scalable total synthesis of (–)-Bipinnatin J…
This is how you enable uptake of a new method! Hats off to the Knight Chemicals team for making a hydrazides coupling starter kit tailor made for medicinal chemists! Obviously I’m biased since I adore @BaranLabReads chemistry and the folks that develop it but dang what a product.
Simplifying Synthesis with Radical Cross-Coupling | drughunters.com/44dDB9V The recording of Phil Baran's (@BaranLabReads) Flash Talk, "Simplifying Synthesis with Radical Cross-Coupling" is now available on our YouTube Channel. Phil highlights how his group combines…
Final version out today in @J_A_C_S : pubs.acs.org/doi/full/10.10…
Simple, Enantiocontrolled Azetidine Library Synthesis via Strain Release Functionalization of 1-Azabicyclobutanes. A fantastic collaboration with the Cravatt lab. A simple, modular, programmable approach to access complex stereopure azetidines through strain-release…
🧪 New in Org. Process Res. Dev.: Researchers leveraged ElectraSyn for a scalable anodic oxidation flow process to synthesize (R)-Troloxamide Quinone (EPI‑589) with high yield and greener chemistry! ⚙️🔋 #electrosynthesis #ElectraSyn #GreenChemistry pubs.acs.org/doi/full/10.10…
Our recent work in steroid synthesis, which features a tandem Negishi/Heck cross-coupling and a Baran reductive olefin coupling (BROC), is now out in @J_A_C_S: pubs.acs.org/doi/10.1021/ja…
Final version has appeared today in @NatureCatalysis : nature.com/articles/s4192…
Anomeric Nitroamide Enabled, Cobalt Catalyzed Alkene Hydronitration: Appearing today in @ChemRxiv : chemrxiv.org/engage/chemrxi… Tertiary nitroalkanes, as well as its reduced products, α-tertiary amines, play an essential role in drug discovery either as key synthetic precursors or…
Very fruitful collaboration with @Malins_Lab and @BaranLabReads on making BCPs without propellane! In @ChemRxiv: bit.ly/43ar8lC Congrats to Andrii (@Anslob11) and Flynn (@flynn_attard) for the heavy lifting!
We are proud to share our work on a Self-Optimizing, Closed-Loop Electrochemical Platform! Appearing on @ChemRxiv today: chemrxiv.org/engage/chemrxi… Highlights of the work below: (1/n)
Proteomic Ligandability Maps of Phosphorus(V) Stereoprobes Identify Covalent TLCD1 Inhibitors | Journal of the American Chemical Society @scrippsresearch @BaranLabReads pubs.acs.org/doi/10.1021/ja…
Appearing today in @Nature : nature.com/articles/s4158…
🚨RADICAL RETHINK: STEREORETENTIVE CROSS COUPLING UNLOCKED🚨 Today in @ChemRxiv (chemrxiv.org/engage/chemrxi…) the first method for stereoretentive radical cross-coupling is disclosed. No fancy ligands or redox needed—just a Ni-diazene twist. 120 years after Gomberg, a new chapter…
⌬⌬⌬Heterocycles 2025⌬⌬⌬ Coming on April 7 (see attached syllabus)! This year will be a reverse classroom format wherein all new material will be discussed with problem solving sessions including real-world consulting questions. Aspiring drug hunters and seasoned veterans:…
Alkyl hydrazides are proving to be game-changers across many transformations, including Ni-catalyzed C-H activation! For fellow C-H activation nerds 🤓, one point not to miss: the amine base used for radical generation plays a critical role in the C–H activation step.
Ni-Catalyzed C–H Alkylation of (hetero)arenes: Super simple, broad scope, enabled by sulfonylhydrazides! Appearing today in @ChemRxiv (chemrxiv.org/engage/chemrxi…). An awesome joint venture with the amazing @EngleLab. Quick Summary: A new method for facile C–H alkylation of a…