Avantika Gupta

@AvanGupta

Postdoc @MSKCancerCenter studying mutagenesis and resistance mechanisms

NYC

Joined August 2018

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83Followers

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Avantika Gupta@AvanGupta · May 16

So excited to share our latest work with Sarat Chandarlapaty, @antoniomarraMD, Andrea Gazzo @MSKCancerCenter out today in @NatureGenet! We uncover the function and mechanism of APOBEC3-driven therapy resistance in breast cancer. 🧵 1/ nature.com/articles/s4158…

AvanGupta's tweet card. Nature Genetics - Analysis of a large cohort of metastatic breast cancer samples shows that APOBEC mutational signatures are enriched in post-treatment samples. APOBEC activity was also associated...

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Avantika Gupta Retweeted

Rei Kudo_MDPhD@Reik0110 · Dec 14

Honored to present our work on mechanism of mtTP53 in escaping CDK4/6i-induced geroconversion linked to the lack of long-term disease control. Grateful to @NeilVasan for highlighting our research in the Basic Science Year in Review! #SABCS24

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Avantika Gupta Retweeted

Memorial Sloan Kettering Cancer Center@MSKCancerCenter · May 16

A new study in @NatureGenet from MSK's Dr. Sarat Chandarlapaty and colleagues investigates how APOBEC3 #mutagenesis drives therapy resistance in #BreastCancer. Learn more: go.nature.com/45kkqfg

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Avantika Gupta@AvanGupta · Apr 29

Thank you for your support! Excited to share the story with everyone soon!

DDr. Ariella Hanker@AriellaHanker · Apr 29

Once again excellent work by @AvanGupta showing that #APOBEC3 drives resistance causing mutations. #AACR25 10.1101/2024.04.29.591453 now in press @NatureGenet

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Avantika Gupta@AvanGupta · Apr 28

Sarat Chandarlapaty expertly summarizing our work on how underlying genomic instability in breast cancer leads to therapy resistance! Come see me expand on the role of APOBEC3 mutagenesis in these processes tomorrow morning at #AACR25!

AvanGupta's tweet image. Sarat Chandarlapaty expertly summarizing our work on how underlying genomic instability in breast cancer leads to therapy resistance! Come see me expand on the role of APOBEC3 mutagenesis in these processes tomorrow morning at #AACR25!

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Avantika Gupta Retweeted

VJ Oncology@VJOncology · Jan 13

🎥@AvanGupta of @MSKCancerCenter discusses APOBEC3 signatures as biomarkers of poor outcomes in metastatic breast cancer. Targeting APOBEC-PIK3CA mutations may boost PI3K-alpha inhibitor sensitivity: ➡️ow.ly/TKE850UAkYO⬅️ @SABCSSanAntonio #SABCS24 #BCSM #breastcancer

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Avantika Gupta Retweeted

VJ Oncology@VJOncology · Jan 6

🎥@AvanGupta of @MSKCancerCenter discusses resistance to trastuzumab deruxtecan (T-DXd) in HER2-low breast cancer. EGFR overexpression limits uptake, but adding cetuximab restores efficacy: ➡️ow.ly/Lt8Q50UAkJS⬅️ @SABCSSanAntonio #SABCS24 #BreastCancer #BCSM #ImmunoOnc

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Avantika Gupta Retweeted

Dr. Ariella Hanker@AriellaHanker · Dec 12

How does a tumor acquire all those resistance promoting alterations in the first place? Kudos to @AvanGupta @MSKCancerCenter for defining the role of #APOBEC3 mutagenesis in this process. #SABCS24

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