Anzy Miller
@AnzyMiller
Research Fellow, University of Manchester
Our innovative study brings out the distinction between single cell and population-level #dynamic regulation. Single cell #oscillators can behave abnormally, despite this the population is normal due to cell #coupling mediated compensation. @Dev_journal journals.biologists.com/dev/article/15…
The day is FINALLY here! The green light has been given by Swedish authorities for a first-in-human clinical trial with the stem cell therapy STEM-PD for treatment of Parkinsons disease! cam.ac.uk/research/news/… @ParmarLab @SCICambridge @BrainRepair_VGB @Kirkeby_Lab
🚨we’re looking for a Postdoc (2-years initially) 🐭⌛️ 📩 drop an email for further info Closes Jan 31st
VACANCY: Postdoctoral Research Scientist Looking for a new role this year? Check out this opportunity to contribute to our understanding of tempo in mammalian development ⏰ babrahaminstitute.livevacancies.co.uk/#/job/details/…
!!Job advert alert!! We are looking for an enthusiastic postdoc with molecular biology expertise and a strong interest in developmental and/or cancer biology to join our team. Apply before Feb 5th: thenode.biologists.com/jobs/post-doc-…
We identified that the #SOX2 protein oscillates every 17h in proliferative and quiescent #glioblastoma stem cells. Interestingly, the #OscoNet algorithm predicted thousands more genes to oscillate 🤯 Our paper is out: nature.com/articles/s4159…
Yay my decoding NGN3 #oscillations paper is now in review, fingers crossed for a friendly reviewer 3 🤣
How do cells decode #TF oscillations and how does this impact development? We find #NGN3 protein oscillates in #pancreatic endocrine cells, #oscillations are likely decoded via fold-change and impact on the timing of differentiation, but not fate choice: papers.ssrn.com/sol3/papers.cf…
We are looking for a talented, self-motivated and collegial post-doc, with passion for #liveimaging, molecular biology expertise and a desire to understand the mechanisms of #cellstatetransitions in #development and #cancer. Apply before June 10th! jobs.manchester.ac.uk/internal/displ…
A new preprint from us! We use the SunTag system to image translation from single mRNAs in the Drosophila embryo and uncover translational regulation of the zygotic hunchback mRNA. Work by @DaisyJVinter, @Caro_Hoppe, Cath Sutcliffe, and @TomMinchington biorxiv.org/content/10.110…
In the latest preprint a phase-dependent relationship between Hes1 and cell-cycle is shown to underlie #cellcycle length heterogeneity in ER+ #breastcancer cells. Congratulations to the authors @nitin_sabherwal @Andyrowntree @JochenKursawe @papalopulu biorxiv.org/content/10.110… 1/6
Excited to see that my first, first-author paper with @samgriffjon and @PapalopuluLab is now out! Do you work on dynamically expressed proteins? Probably. Check to see if your favourite transcriptional regulator features in our results. nature.com/articles/s4159…
I'm excited to share my first first-author publication that is out now in @Dev_Cell. An exciting collaboration between @TheAsheLab, @MagnusRattray and @TomMinchington. We show how the Drosophila embryo decodes the BMP signaling gradient at single-cell resolution. (1/7)
New Article online now at Dev Cell: Modulation of the Promoter Activation Rate Dictates the Transcriptional Response to Graded BMP Signaling Levels in the Drosophila Embryo - zpr.io/HzDW3
Cells in tissue are using ‘group chats’ to make decisions! Multiscale synthesis of fine-grained protein expression of HES5 reveals locally co-ordinated clusters and stripes that control rate of progenitor differentiation. bioRxiv: biorxiv.org/content/10.110… 1/5
WE’RE HIRING! Are you a cell or developmental biologist? Are you interested in how cells coordinate multiple processes during tissue morphogenesis? Join our team! We’re looking for TWO new research associates! nature.com/naturecareers/… #sciencejobs #postdoc @jobRxiv @the_Node
How do cells make cell state transitions? @PapalopuluLab @XimenaSoto40 et al reveal a #miRNA-driven mechanism counteracting noise and ensuring oscillatory expression of transcriptional regulators during #zebrafish neurogenesis embopress.org/doi/10.15252/e…
Latest preprint by @TomMinchington @samgriffjon decomposes gene regulation into simple motifs showing that dual feedback motifs (auto-regulatory TF+microRNA) are prevalent and thus could drive dynamic expression in many genes found in human. biorxiv.org/content/10.110…
Exciting PhD opportunity with the up and coming PI of the moment Dr Guilherme Costa. If you are interested in RNA localisation, angiogenesis or ideally both then you should check out this fantastic opportunity: findaphd.com/phds/project/r…
Nice work from our neighbours and collaborators here in the CSCB/ @bmssheffield together with Tariq Enver's group on how to "trap" a human mesoderm-biased pluripotent stem cell state through WNT signalling fine-tuning: biorxiv.org/content/early/…