Vincent Alcazer
@AlcazerVincent
MD, Hematologist @CHUdeLyon | PhD in Immunology & Bioinformatics Myeloid malignancies (AML, MPN, AA, PNH) Looking for Human Endogenous Retroviruses everywhere
Looking for a free open-source software with a user-friendly graphical interface for data analysis? Consider using #StatAid! #RStats Online version: alcazerv.shinyapps.io/StatAid/ Github: github.com/VincentAlcazer… Paper: joss.theoj.org/papers/10.2110…
How I treat patients who are refractory to platelet transfusions sciencedirect.com/science/articl…
Proteostasis disruption in inherited bone marrow failure syndromes ashpublications.org/blood/article-…
The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets dlvr.it/TLyB5j
Single-cell spatial transcriptomics reveals immunotherapy-driven bone marrow niche remodeling in AML | Science Advances science.org/doi/10.1126/sc…
How I treat Wiskott-Aldrich syndrome ow.ly/8yua50WmijX #HowITreat #genetherapy #immunobiologyandimmunotherapy #plateletsandthrombopoiesis #transplantation
📢 Out in @NEJMEvidence 👫N=1132 pts; age 18-60 🔹ND #AML 🔹Consolidation with IDAC vs HIDAC 🔹5-yr OS = 59% vs 58% 🔹Lower incidence of myelosuppressio & AEs with IDAC ➡️ IDAC non inferior to HIDAC #leusm @OncoAlert evidence.nejm.org/doi/pdf/10.105…
Identification of Hepatic-like EPO as a Cause of Polycythemia | New England Journal of Medicine nejm.org/doi/full/10.10…
AML diagnostics in the 21st century: Use of AI sciencedirect.com/science/articl…
Microsoft claims their new AI framework diagnoses 4x better than doctors. I'm a medical doctor and I actually read the paper. Here's my perspective on why this is both impressive AND misleading ... 🧵
A molecular signature predicts hematologic evolution in polycythemia vera patients nature.com/articles/s4137…
Use of machine learning techniques to predict poor survival after hematopoietic cell transplantation for myelofibrosis ashpublications.org/blood/article-…
Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: a practical guide to diagnosis and management pubmed.ncbi.nlm.nih.gov/40253543/
Impact of HLA alloimmunization on clinical outcomes of severe aplastic anemia treated with immunosuppressive therapy ashpublications.org/bloodadvances/…
Here is how I would start learning bioinformatics. 👇 divingintogeneticsandgenomics.com/post/bioinfo-r…
🎉Finally out🎉 Our study showed value of low dose splenic irradiation and transplantation as part of a curative approach in myelofibrosis with refractory splenomegaly: - significant spleen size reduction - excellent engraftment #mpnsm @ASTCT_Journal astctjournal.org/article/S2666-…
NEW Viewpoint: Importance of sample size on the quality and utility of #AI-based prediction models for healthcare. Read it here: thelancet.com/journals/landi…
Role of allo-HCT in “nonclassical” MPNs and MDS/MPNs: recommendations from the PH&G Committee and the CMWP of the EBMT ashpublications.org/blood/article/…
Treating late-onset high-grade immune effector cell-associated hematotoxicity unresponsive to standard therapies with high-dose intravenous immunoglobulin. Could this be a new avenue for managing refractory cases? haematologica.org/article/view/1…
Iron Deficiency in Adults jamanetwork.com/journals/jama/…
Many of the inherited bone marrow failure syndromes are associated with myeloid malignancy predisposition, and a subset carry an increased risk of both myeloid and lymphoid malignancies. ow.ly/3q9t50VXk0i #myeloidneoplasia #lymphoidneoplasia