Structural Biology

Acta Crystallographica Section D - Structural Biology welcomes the submission of articles covering all aspects of structural biology, with a particular emphasis on the structures of biological macromolecules or the methods used to determine them. ➡️ journals.iucr.org/d/

Structural studies of the intrinsically disordered regions of human SFPQ reveal that it is capable of swapping dimer partners with itself  @uwanews @unimelb @ActaCrystD @IUCr #PhaseSeparation #Disorder #Flexibility doi.org/10.1107/S20597…

Grigore Pintilie et al.: Q-score as a reliability measure for protein, nucleic acid and small-molecule atomic coordinate models derived from 3DEM maps #CryoEM #QScores #Validation @ucsandiego... #IUCr journals.iucr.org/paper?S2059798…

Our July issue is out tinyurl.com/2u2cj472 On the cover: structural studies of the intrinsically disordered regions of human SFPQ reveal that it is capable of swapping dimer partners with itself. Find out more at doi.org/10.1107/S20597…

Fabio Casagrande et al.: A high-resolution data set of fatty acid-binding protein structures. I. Dynamics of FABP4 and ligand binding #NMRDynamics #MicelleAndBicelleBinding #ResidualLigands ... #IUCr journals.iucr.org/paper?S2059798…

Elspeth F. Garman: Perspective on a large-scale ligand structure characterization ... #IUCr journals.iucr.org/paper?S2059798…

To investigate coagulation factor XII ligand binding, crystal structures of its five N-terminal domains and of its FnII domain bound to Zn2+ were determined @UniofNottingham @universityleeds #FactorXII #FibronectinTypeIIDomain #KringleDomain doi.org/10.1107/S20597…

It's day 4 of #ISBMECCB25 so do drop by the @IUCr stand! Now featuring the IUCr Journals tablecloth and a rare appearance by our Managing Editor!

We're at the #ISMBECCB2025! Come and talk to us about the @IUCr and our journals!

Crystal structure of coagulation factor XII N-terminal domains 1–5: conformational change of the factor XII fibronectin type II latch loop Read more at doi.org/10.1107/S20597…

The upgraded DoubleMesh&Collect method automatically analyses the diffraction images of two mesh scans @ActaCrystD @IUCr #Dozor #DozorM2 #Resheteau doi.org/10.1107/S20597…

A preconditioned stochastic gradient descent approach can potentially enable a simple and unified approach to ab initio reconstruction and high-resolution refinement with faster convergence speed and higher flexibility #CryoEM #HomogeneousRefinement doi.org/10.1107/S20597…

Cong T. S. Van et al.: Probabilistic single-particle cryo-EM ab initio 3D reconstruction in SIMPLE #CryoEM #SingleParticle #Reconstruction ... #IUCr journals.iucr.org/paper?S2059798…

Awarded every three years, the Ewald Prize includes a medal, certificate and financial award. The 2026 Prize will be presented at the Congress in Calgary, Canada, in August 2026 Deadline: 30/11/2025 Details: iucr.org/iucr/ewald-pri…

Preparing for successful protein crystallization experiments doi.org/10.1107/S20532…

M​uhammad Saleem et al.: Crystal structure of coagulation factor XII N-terminal domains 1–5 #FactorXII #FibronectinTypeIIDomain #KringleDomain @UniofNottingham @universityleeds... #IUCr journals.iucr.org/paper?S2059798…

Heidar J. Koning et al.: Structural dynamics of IDR interactions in human SFPQ and implications for liquid–liquid phase separation #PhaseSeparation #Disorder #Flexibility @uwanews @unimelb... #IUCr journals.iucr.org/paper?S2059798…

Igor Melnikov et al.: Enhanced capabilities for multi-crystal data collection based on double mesh scans #Dozor #DozorM2 #Resheteau ... #IUCr journals.iucr.org/paper?S2059798…

Bogdan Toader et al.: Efficient high-resolution refinement in cryo-EM with stochastic gradient descent #CryoEM #HomogeneousRefinement #StochasticGradientDescent @unewhaven... #IUCr journals.iucr.org/paper?S2059798…

Johannes Elferich et al.: In situ high-resolution cryo-EM reconstructions from CEMOVIS #ElectronTomography #IntegrativeStructuralBiology #Imaging @unibern... #IUCr journals.iucr.org/paper?S2052252…