ASM

Adaptation of M. tuberculosis to acidic niches within the host is vital to establish the disease. In #MRAJournal, researchers present a high-density transposon mutant sequencing library data set identifying genetic determinants of acid growth arrest. asm.social/2vL

Best known for its use in gene therapy, adeno-associated virus (AAV) is also a surprisingly versatile vaccine platform. This #JVirology review highlights engineering efforts to improve vaccine efficacy, plus advantages/disadvantage of AAV-based vaccines. asm.social/2vK

Bats rarely bite, but when they do, the consequences can be deadly. While dog and terrestrial wildlife bites once topped the list, it’s now bats that are behind most rabies deaths in America. asm.social/2vH @RodneyRohde

We're thrilled to welcome Dr. Veronica Garcia as Scientific Director of ASM's new AEM unit. Her leadership, alongside AEM Chair Dr. Jay Lennon, will advance ASM's strategic vision in biodiversity, biofuels, synthetic biology & more. Learn more: asm.social/2vG

By establishing an experimental evolution system using Pseudomonas bijieensis 2P24 in the wheat rhizosphere, scientists show that bacteria enhance colonization ability by fine-tuning flagellar number, revealing a novel adaptive mutation. #mBio: asm.social/2vE

The answer to last week’s #CaseStudySaturday question is 🦠… B. Cryptococcus! Get the details and learn more when you watch the video on the #ASMClinMicro Case Study page: asm.social/2vB

Did you know that some microbes can simultaneously respire aerobically and anaerobically, even in fully oxic environments? @kartiksaiyer elaborates on a flexible strategy that reshapes traditional understanding of microbial metabolism: asm.social/2vy

In #JBacteriology, researchers show that the C-terminal domain of the T2SS "clamp" protein EpsC is required for secretion of only a subset of substrates in Vibrio cholerae, adding to the growing body of evidence about substrate selection by the T2SS. asm.social/2vx

#MicrobiologyMonday: What is love?♥️ It might start in the gut. This #mSystems paper explores the hypothesis that gut microbes can influence the hormonal and neural systems linked to love-associated emotions via the microbiota-gut-brain axis. Read now: asm.social/2vw

Take a break from the July heat with a #CaseStudySaturday! A man w/ HIV came to the ED with headaches, fever and chills, diarrhea & depressed mood. He stopped meds 9 months prior and had a temp of 102.6 °F. Get the answer on Tuesday: asm.social/2vt #ASMClinMicro

A genome-wide CRISPR knockout screen in human CD4+ T cells identifies the activating transcription factor 1 (ATF1) as an activator of HIV gene transcription, with elevated expression levels in cells carrying transcriptionally active provirus. #mBio: asm.social/2vs

Vibrio vulnificus, a so-called “flesh-eating bacterium,” causes severe wound infections. What are the mechanisms behind its ability to destroy host tissues—and why does it destroy them at all? asm.social/2vq

In #ASMCaseReports, researchers describe a case of gastrointestinal tuberculosis (GI TB) in an immunocompetent patient; the report highlights the importance of having a high index of suspicion for unusual presentations of tuberculosis. Read now: asm.social/2vp

Human toxocariasis is a zoonotic parasitic infection caused by the larvae of dog & cat roundworms. A comprehensive review in #ClinMicroRev analyzes existing research to provide a detailed and updated understanding of this globally important infection. asm.social/2vi

Bacteria can be selfish..."Selfish" bacterial uptake of polysaccharides minimizes release of smaller sugars into the environment, ensuring cells get a return on their enzymatic invest. This #JournalSpectrum paper outlines how to identify selfish bacteria: asm.social/2vh

How FMTs are used to mitigate health concerns in wild animals in captivity. Learn about the milk microbiome from the Smithsonian milk repository, the largest collection of exotic animal milks in the world, and the science behind eating poo (Coprophagia). asm.social/2vf

Bacteria isolated from biodiverse habitats on the Mediterranean island Crete yield biopesticidal metabolites against mosquito larvae, with 3 select isolates producing metabolites capable of causing 100% mortality within 24 hours of exposure. #AppEnvMicro: asm.social/2ve

Using experimental evolution in host-mimicking media, researchers show that inflammation-like environments limit the loss of quorum sensing—a common adaptation during chronic infections—in Pseudomonas aeruginosa. Learn more in #mSystems: asm.social/2vd

On July 30 at 1 p.m. ET, join moderator Robert Bonomo, M.D., and a panel of experts in antimicrobial agents and resistance (AAR) to discuss the evolution of the pharmaceutical industry.💊 Register at: asm.social/2vc

Registrations are open for the next ASM Microbial Quorum talk; this time in #Hyderabad at @ccmb_csir, kindly hosted by Drs. @sriram_varahan and Vinay Nandicoori. RSVP: bit.ly/Microbial-Quor… @ASMicrobiology