ACR_Journals

👏 Join us in congratulating the 2024-5 graduating class of Rheum With a (re)View, a mentoring program dedicated to developing a strong pipeline of peer reviewers. 📖 See the graduates & learn more about the program → acr.tw/3xvknyR

Characterizing circulating microparticles (MPs) in both symp. & asymp. ANA+ individuals revealed similarly elevated # of MP immune complexes, but with IgGs significantly less pro-inflammatory, suggesting instead differences in altered IgG sialylation A&R doi.org/10.1002/art.43…

Analysis of whole-exome seq data from MyCode & BioMe biobanks investigated assoc between UBA1 VAF and VEXAS disease manif. Results showed ↑VAF resulted in more severe disease & higher penetrance, while ↓VAF had incomplete penetrance & milder disease A&R doi.org/10.1002/art.43…

Mouse model investigated mechanisms of how ADAM9 alters T cell metabolism and contributes to organ damage in autoimmune disease. Results showed ADAM9 promotes GLUT1 expression and glycolysis in Th17 cells by cleaving IGFBP4 and releasing IGF-1 A&R doi.org/10.1002/art.43…

Qualitative study explored the lived and care experience of Australian adults with chronic musculoskeletal shoulder pain Arthritis Care & Research doi.org/10.1002/acr.25…

This study explored lupus low disease activity state (LLDAS) as a treatment target for lupus nephritis. Results showed LLDAS is an attainable target assoc w/ reduced renal relapse in LN. LLDAS attainment was also assoc w/ renal function preservation AC&R doi.org/10.1002/acr.25…

Investigating pesticide use and rheumatoid arthritis risk among female spouses of licensed pesticide applicators in the Agricultural Health Study showed some insecticides may contribute to risk of RA. Tables with ORs 👇 Complete footnotes in article A&R doi.org/10.1002/art.43…

Plasma samples from untreated patients with active JIA were analyzed for ANA specificities. Results showed chromatin was the main target of autoantibody reactivity in JIA, and 20% of JIA patients had reactivity to dsDNA-nucleosome complexes A&R doi.org/10.1002/art.43…

Assessing whether patient decision aid for pts with SLE differs by viewing experience revealed setting & modality had minimal effect on perceived patient acceptability & satisfaction. Uninterrupted & complete viewing was assoc. w/ better SDM outcomes AC&R doi.org/10.1002/acr.25…

Among 223 patients with scleroderma renal crisis, 24% were late-onset (>5 years), with mean onset 12 years after initial diagnosis of systemic sclerosis. Exposure to steroids was significantly associated with late-onset scleroderma renal crisis AC&R doi.org/10.1002/acr.25…

Clinical images in A&R show progression of rheumatoid arthritis damage in a patient with long history of arthritic hip pain who discontinued meds shortly after starting them, taking only prednisone for symptom relief Images: (A) x-ray 10 years prior showing joint destruction of…

New editorial on the below study in Arthritis & Rheumatology: "Gout patients suffer disproportionately from cardiovascular disease and are regular consumers of antiinflammatory drugs. Prospective trials of colchicine for long-term cardiovascular prevention, and now for…

Check out these new studies published this week in Arthritis & Rheumatology 👓 📖 🛋️ Adverse pregnancy outcomes among women with SSc in the Swedish Medical Birth Register doi.org/10.1002/art.43… Immunology series: Mechanisms of B Cell Tolerance in Health and Autoimmunity…

More great articles this week in Arthritis Care & Research! 🤩 Cost impact of switching patients with inflammatory arthritis to a biosimilar in BC, Canada doi.org/10.1002/acr.25… Review: race-based practices in pediatric rheumatology and alternatives to race-based practices…