Brennan Overhoff

Thrilled to announce our next event @aginginit: the Muscle Aging Science & Translation symposium @harvardmed, featuring @davidjglassMD @Regeneron, Anne-Ulrike Trendelenburg @Novartis, Andrew Adams @EliLillyandCo, @JeffNippard, @BradSchoenfeld, @RogerFielding5 @TuftsUniversity,…

I taught an LLM to optimize proteins. It proposed a better carbon capture enzyme. Introducing Pro-1, an 8b param reasoning model trained using GRPO towards a physics based reward function for protein stability. It takes in a protein sequence + text description + previous…

This is cool: GLP1 trials are looking more and more like multimorbidity-prevention (i.e. aging?) trials? Look at Lilly’s SURMOUNT trial for tirzepatide vs e.g. Novo Nordisk’s SELECT: 1) more general endpoints 2) broader study population short🧵